What does this research mean for the field?

The publication of the pre-eclampsia core outcome set (COS) increased the number of COS outcomes reported per trial, but did not significantly increase the overall proportion of trials reporting at least one COS outcome, indicating ongoing gaps in standardized outcome reporting. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate the uptake of the pre-eclampsia core outcome set in randomized controlled trial registrations before and after publication, and to identify factors associated with its implementation.

September 10, 2026Maternal-Fetal MedicineOpen Access

Assessing the Uptake of the Core Outcome Set in Randomized Controlled Trial Registrations for the Treatment of Pre-eclampsia Before and After Its Publication

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Authors

KAKailibinuer Ailimu ZWZiyan Wang WLWenqiang Li

Discussion

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Overview

Cross-sectional registry study demonstrates modest uptake of core outcome sets in pre-eclampsia trial registrations, highlighting persistent gaps in neonatal endpoints and standardized definitions.

Key Points

To evaluate the uptake of the pre-eclampsia core outcome set in randomized controlled trial registrations before and after publication, and to identify factors associated with its implementation.
Screened randomized controlled trial registrations on pre-eclampsia treatment from the World Health Organization International Clinical Trials Registry Platform, including N = 279 eligible trials.
Extracted trial characteristics in duplicate and evaluated the consistency between registered outcome definitions and core recommendations.
Identified factors independently associated with core outcome set uptake using multivariable logistic and negative binomial regression models.
Post-publication registration was independently associated with a higher number of core outcomes reported per trial (adjusted RR: 1.53, 95% CI: 1.02–2.29, P = 0.039), but did not significantly increase the likelihood of reporting at least one core outcome (adjusted OR: 1.31, 95% CI: 0.73–2.35, P = 0.361).
Overall, 47.0% (n = 131/279) of trial registrations reported at least one specific core outcome, with maternal outcomes adopted more frequently (39.4%, n = 110) than neonatal outcomes (21.5%, n = 60).
Consistency between registered definitions and core recommendations ranged from 0% to 91.4%, with only two individual outcomes exceeding 50% alignment.

Cite This Study

Ailimu et al. (2026) studied this question.

synapsesocial.com/papers/6aa27bcf58559d80afc753e0 https://doi.org/10.1097/fm9.0000000000000378

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September 10, 2026Maternal-Fetal MedicineOpen Access

Assessing the Uptake of the Core Outcome Set in Randomized Controlled Trial Registrations for the Treatment of Pre-eclampsia Before and After Its Publication

View Full Paper

Ask AI

Bookmark

Authors

KAKailibinuer Ailimu ZWZiyan Wang WLWenqiang Li

Discussion

Member takes

Overview

Cross-sectional registry study demonstrates modest uptake of core outcome sets in pre-eclampsia trial registrations, highlighting persistent gaps in neonatal endpoints and standardized definitions.

Key Points

To evaluate the uptake of the pre-eclampsia core outcome set in randomized controlled trial registrations before and after publication, and to identify factors associated with its implementation.
Screened randomized controlled trial registrations on pre-eclampsia treatment from the World Health Organization International Clinical Trials Registry Platform, including N = 279 eligible trials.
Extracted trial characteristics in duplicate and evaluated the consistency between registered outcome definitions and core recommendations.
Identified factors independently associated with core outcome set uptake using multivariable logistic and negative binomial regression models.
Post-publication registration was independently associated with a higher number of core outcomes reported per trial (adjusted RR: 1.53, 95% CI: 1.02–2.29, P = 0.039), but did not significantly increase the likelihood of reporting at least one core outcome (adjusted OR: 1.31, 95% CI: 0.73–2.35, P = 0.361).
Overall, 47.0% (n = 131/279) of trial registrations reported at least one specific core outcome, with maternal outcomes adopted more frequently (39.4%, n = 110) than neonatal outcomes (21.5%, n = 60).
Consistency between registered definitions and core recommendations ranged from 0% to 91.4%, with only two individual outcomes exceeding 50% alignment.

Cite This Study

Ailimu et al. (2026) studied this question.

synapsesocial.com/papers/6aa27bcf58559d80afc753e0 https://doi.org/10.1097/fm9.0000000000000378

View Full Paper

Ask AI

Bookmark