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September 10, 2026Journal of Cerebral Blood Flow & Metabolism

EXPRESS: Middle Meningeal Artery Embolization: Expansion of Therapeutic Applications Driven by Neurovascular-Immune Mechanisms

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Authors

LZLi ZhangZPZhenghong PengTTTianqi Tu

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Overview

Review reveals neurovascular-immune mechanisms driving middle meningeal artery embolization efficacy across brain disorders, indicating therapeutic utility beyond simple vascular occlusion.

Key Points

  • Synthesize experimental and clinical evidence to identify the shared biological and neurovascular-immune mechanisms driving the therapeutic efficacy of middle meningeal artery embolization across distinct neurological diseases.
  • Synthesized experimental and clinical studies evaluating middle meningeal artery embolization across emerging indications, focusing on chronic subdural hematoma, migraine, and glioblastoma.
  • Identified that the middle meningeal artery operates as an integrated neurovascular-immune interface regulating nociception, inflammation, angiogenesis, and meningeal immunity.
  • Showed that embolization provides cross-disease therapeutic benefits beyond vessel occlusion by halting abnormal vessel growth, reducing neurogenic inflammation, and remodeling the local immune microenvironment.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/6aa27bcf58559d80afc75564https://doi.org/10.1177/0271678x261478954
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