Why the study?
In cardiac sarcoidosis, the risk and predictors of new-onset AF are poorly known.
What is the incidence and what are the predictors of new-onset atrial fibrillation in patients with newly diagnosed cardiac sarcoidosis?
Population
118 patients with AF-naive newly diagnosed cardiac sarcoidosis
Comparison
Presence vs absence of atrial 18F-FDG uptake and other imaging characteristics
Design
Cohort study
Follow-up
Median, 3 years
Key result
In newly diagnosed cardiac sarcoidosis, atrial 18F-FDG uptake was an independent predictor of new-onset atrial fibrillation (HR 6.01; 95% CI 2.64-13.66; P<0.001).
Authors
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Should not change practice; hypothesis-generating for atrial FDG uptake in AF risk stratification in cardiac sarcoidosis.
Cohort (n=118)
What is the incidence and what are the predictors of new-onset atrial fibrillation in patients with newly diagnosed cardiac sarcoidosis?
Hazard Ratio: 6.01 (95% CI 2.64–13.66)
Absolute Event Rate: 55% vs 18%
p-value: p=< 0.001
In newly diagnosed cardiac sarcoidosis, future atrial fibrillation is common and strongly predicted by atrial inflammation detected on 18F-FDG PET and atrial enlargement.
Niemelä et al. (2022) conducted a cohort in Cardiac sarcoidosis (n=118). Atrial 18F-FDG uptake vs. No atrial 18F-FDG uptake was evaluated on New-onset atrial fibrillation (estimated 5-year incidence) (HR 6.01, 95% CI 2.64-13.66, p=< 0.001). In newly diagnosed cardiac sarcoidosis, atrial 18F-FDG uptake was an independent predictor of new-onset atrial fibrillation (HR 6.01; 95% CI 2.64-13.66; P<0.001).