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January 1, 2012Chemical Communications

I-Motif formation in gene promoters: unusually stable formation in sequences complementary to known G-quadruplexes

John Brazier Arti N. Shah Geoffrey D. Brown

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Abstract

I-motif formation has been confirmed in a number of gene promoter sequences known to form G-quadruplex structures. I-motif formation can occur close to physiological temperature and pH for h-tert and PDGF-A. The i-motif structure formed by a HIF-1α promoter sequence shows unexpected stability near neutral pH.

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Brazier et al. (2012) studied this question.

synapsesocial.com/papers/6aa28cc474fc654bd03236eb https://doi.org/10.1039/c2cc30863k

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