An enantioselective domino reaction of 4‐bromo‐3‐oxobutanoates with isatin‐derived ketimines was developed to construct 3‐amino‐2‐oxindoles with a quaternary stereocentre. In the presence of 1 mol‐% of a bifunctional squaramide organocatalyst, the desired products were achieved in high yields (90–97 %) and with excellent enantioselectivities (92–99 % ee).
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Wang et al. (2013) studied this question.
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