Key result
Review links classical stress concepts to modern CNS arousal mechanisms and their dysregulation in disease.
Understanding the relationship between CNS arousal and stress mechanisms is crucial as their dysregulation is linked to many diseases.
Dysregulation of stress and CNS arousal pathways may inform clinical evaluation of related diseases; leaves open integrated mechanistic trials.
In the centennial year of the birth of Hans Selye, this review compares his classical concepts of stress with a modern approach to mechanisms of CNS arousal. Relations between the two concepts are described. Neuroanatomical, neurophysiological, and functional genomic mechanisms underlying CNS arousal are briefly reviewed. Controls over stress responses and arousal are compared to particular concepts of control system engineering. Understanding these two systems is of crucial importance because their dysregulation is associated with large numbers of disease states.
No takes yet. Share an insight, caveat, or question.
Pfaff et al. (2007) reported a review. Mechanisms of CNS arousal and stress was evaluated. This review compares classical concepts of stress with modern mechanisms of CNS arousal, highlighting their neuroanatomical relationships and the importance of their dysregulation in disease states.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: