The enantioselective addition of diethylzinc to aldehydes in the presence of a catalytic amount of several chiral diamines, (S)-2-(N,N-disubstituted aminomethyl)pyrrolidines, was studied. Relatively high selectivity was achieved in the case of aromatic aldehydes by employing 15 mol% of (S)-2-(1-pyrrolidinylmethyl)pyrrrolidine.
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Asami et al. (1997) studied this question.
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