Key result
Carbamazepine suppresses drug-refractory ventricular extrasystoles in a pediatric patient.
Why the study?
Carbamazepine has demonstrated antiarrhythmic effects, but its utility in managing refractory pediatric ventricular extrasystoles and arrhythmogenic myocardial dysfunction warranted presentation.
Does carbamazepine reduce ectopic activity in a pediatric patient with refractory frequent ventricular extrasystoles and arrhythmogenic myocardial dysfunction?
Case Report (n=1)
Does carbamazepine reduce ectopic activity in a pediatric patient with refractory frequent ventricular extrasystoles and arrhythmogenic myocardial dysfunction?
Carbamazepine may be an effective alternative for managing refractory frequent ventricular extrasystoles and arrhythmogenic myocardial dysfunction in pediatric patients.
May support carbamazepine in refractory pediatric ventricular extrasystoles; leaves open efficacy in controlled trials.
Carbamazepine is a drug that has been used for a long time to treat various neurological and psychiatric disorders. The drug has effect on many body systems and, in particular, on the cardiovascular. The cardiovascular effect of carbamazepine depends on several factors such as the presence/absence of any comorbidities and its plasma concentration. The drug’s antiarrhythmic effect was demonstrated previously in a number of experimental and clinical studies. In this article, we would like to present the clinical case of pediatric patient with frequent ventricular extrasystoles and arrhythmogenic myocardial dysfunction. Several antiarrhythmic drugs were ineffective in this patient, while carbamazepine administration contributed to the decrease in ectopic activity up to minimal values.
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Gordeev et al. (2023) conducted a case report in Frequent ventricular extrasystoles and arrhythmogenic myocardial dysfunction (n=1). Carbamazepine vs. Previous antiarrhythmic drugs was evaluated on Ectopic activity. Carbamazepine administration decreased ectopic activity to minimal values in a pediatric patient with frequent ventricular extrasystoles refractory to other antiarrhythmic drugs.
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