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The efficient repair of double-strand breaks (DSBs) isessential for the maintenance of chromosomal DNA. Inthe absence of repair, DNA breaks can lead to mutations,gene translocations, and cancer. DSBs occur in somaticcells when replication forks stall or are blocked at DNAlesions and are a consequence of the harmful effects ofionizing radiation. In germ-line cells, they are introducedduring meiosis where they serve as the initiating signalfor genetic recombination...
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West et al. (2000) studied this question.
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