Key result
Neurohypophysial peptides constrict chicken pulmonary arteries and magnesium potentiates this vasoconstriction.
Why the study?
Does magnesium potentiate the contractile responses of avian vascular smooth muscle to neurohypophysial peptides?
Does magnesium potentiate the contractile responses of avian vascular smooth muscle to neurohypophysial peptides?
Magnesium potentiates the vasoconstrictor effects of neurohypophysial peptides in avian vascular smooth muscle, suggesting specific peptide-protein interactions at tissue receptors.
No immediate clinical implications from avian data; leaves open magnesium's modulation of peptide vasoconstriction in mammalian pulmonary vessels.
The contractile responses of helically cut vascular strips of chickens to vasoactive agents were studied.2. Large pulmonary arteries were contracted by neurohypophysial peptides, but not by angiotensin, acetylcholine, histamine, 5-hydroxytryptamine, bradykinin or eledoisin. The activity of oxytocin was greater than that of arginine vasopressin.3. Vasodilator effects of oxytocin upon small (200-500 mu diameter) mesenteric and muscular arteries were demonstrable, but inconsistent.4. Magnesium potentiated in a parallel fashion the vasoconstrictor effects of oxytocin and of arginine vasopressin.5. Deamino-oxytocin was potentiated by magnesium. This finding suggests a difference between the peptide-protein interactions of tissue receptors and those of neurophysin.
No takes yet. Share an insight, caveat, or question.
Somlyo et al. (1967) studied this question. Neurohypophysial peptides and magnesium was evaluated on Contractile responses of vascular strips. Neurohypophysial peptides contracted large pulmonary arteries in chickens, and magnesium potentiated the vasoconstrictor effects of oxytocin and arginine vasopressin.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: