Key result
The actual delivered dose intensity of 90Sr/Y beta-radiation for in-stent restenosis did not correlate with changes in intimal hyperplasia volume (P=NS).
Why the study?
Does the actual delivered dose of beta-radiation affect vascular changes in patients with in-stent restenosis?
Observational (n=30)
Does the actual delivered dose of beta-radiation affect vascular changes in patients with in-stent restenosis?
The current dose-prescription protocol of 90Sr/Y radiation for in-stent restenosis provides substantial inhibition of neointimal reproliferation regardless of the actual delivered dose intensity.
Answers are grounded in this paper and cite their sources.
Supports uniform dosing protocols for beta-radiation in restenosis; leaves open whether dose optimization improves outcomes in prospective trials.
BACKGROUND: Observations from previous intracoronary radiation therapy trials noted a considerable discrepancy between the prescribed radiation dose and the dose actually delivered. The aims of this study were to investigate the effect of actual delivered dose on vascular changes and to test the appropriateness of the current dose prescription. METHODS AND RESULTS: Serial volumetric intravascular ultrasound (IVUS) analysis was performed in 30 in-stent restenosis cases treated with a 40-mm (90)Sr/Y source train. The fixed dose was prescribed at 2 mm from the centerline of the source train (18.4 Gy at 2 mm for reference diameter < or =3.35 mm and 23 Gy for diameter > or =3.36 mm). Only stent segments with full radiation coverage and device injury were enrolled and divided into 2-mm-long subsegments (n=202). D(S90)EEM (the minimum dose absorbed by 90% of the external elastic membrane surface) was calculated as the delivered dose corresponding to each segment, assuming that the radiation catheter occupied the same position in the vessel as the IVUS catheter. Mean D(S90)EEM of 23.5+/-5.82 Gy (range 12.3 to 41.7 Gy) was delivered to these subsegments. Overall, intimal hyperplasia volume remained constant from postintervention to follow-up (2.23+/-1.10 to 2.32+/-1.09 mm3/m; P=NS). Regression analysis revealed there was no correlation between delivered dose intensity and changes in intimal hyperplasia volume. No particular dose-dependent complications were appreciated in this delivered dose range. CONCLUSIONS: The current dose-prescription protocol of (90)Sr/Y radiation to native in-stent restenosis lesions may provide substantial inhibition of neointimal reproliferation regardless of the actual delivered dose intensity.
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Morino et al. (2002) conducted an observational in In-stent restenosis (n=30). Delivered dose of 90Sr/Y beta-radiation was evaluated on Changes in intimal hyperplasia volume (p=NS). The actual delivered dose intensity of 90Sr/Y beta-radiation for in-stent restenosis did not correlate with changes in intimal hyperplasia volume (P=NS).
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