Significantly higher frequencies of alloreactive CD4+ T cells responding to nonpermissive than to permissive HLA-DPB1 T-cell epitope disparities

GMOANALYSIS VERSION 2.1.0 is a user-friendly software supporting the statistical analysis methodology recommended by the EFSA GMO Panel with regard to the food and feed safety assessment of genetically modified plants. The software implements all steps of the statistical procedure for the analysis of comparative field trial data, described in EFSA’s guidance for FF risk assessment (EFSA, 2011). The software conducts the simultaneous analysis of the GM plant compared to its control and non-GM reference varieties (test of difference and test of equivalence). Input data of agronomic, phenotypic or compositional analysis from field trials in eight locations where both the GM plant and a comparator plant were grown is required. The analysis is performed using a Residual Maximum Likelihood (REML) mixed model. An output-file listing all the significant differences and the respective equivalence categories is generated.