Key result
Women achieve long-term quality-of-life gains comparable to men after CABG despite slower early recovery.
Why the study?
Sex-specific trajectories of quality of life after isolated CABG and longitudinal differences between women and men needed evaluation.
Does female sex affect the long-term trajectory of health-related quality of life improvement in patients undergoing isolated CABG?
Cohort (n=2,465)
Yes
Does female sex affect the long-term trajectory of health-related quality of life improvement in patients undergoing isolated CABG?
Anticipate slower early QoL recovery in women after CABG; this cohort study leaves open whether targeted interventions improve trajectories.
Objectives: To evaluate sex-specific trajectories of quality of life (QoL) after isolated coronary artery bypass grafting (CABG) and longitudinally assess changes in QoL in women compared with men. Methods: This analysis included patients enrolled in a European multicenter registry (December 2016 to August 2019) who underwent isolated CABG and had complete European QoL-5 Dimension-5 Level (EQ-5D-5L) QoL assessments at baseline and at least 1 follow-up evaluated at 1 month, 1 year, and annually up to 4 years thereafter. The primary outcome was the sex-specific change in EQ-5D-5L index value from baseline. Secondary outcomes included the change from baseline in the individual EQ-5D-5L dimension scores. Mixed-effects models with repeated measures were used to analyze longitudinal changes. Results: < .0001), persisting throughout follow-up. Conclusions: Although women experienced delayed recovery and greater psychological burden in the early postoperative period, they ultimately achieved comparable long-term improvements in QoL.
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Florian et al. (2026) conducted a cohort in Coronary artery disease requiring isolated coronary artery bypass grafting (n=2,465). Female sex vs. Male sex was evaluated on Change from baseline in health-related quality of life (EQ-5D-5L index value). Although women reported lower baseline quality of life and experienced a slower early recovery after coronary artery bypass grafting, their long-term improvements in quality of life were comparable to those of men.
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