What question did this study set out to answer?

To develop and evaluate injectable shear-thinning biomaterials for the localized, pH-responsive delivery of doxorubicin to treat melanoma.

November 12, 2021NanoscaleOpen Access

pH-Responsive doxorubicin delivery using shear-thinning biomaterials for localized melanoma treatment

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Authors

JLJunmin LeePohang University of Science and Technology YWYonggang WangNingbo University CXChengbin XueNantong University

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Implication

Preclinical evaluation demonstrates pH-triggered doxorubicin release from shear-thinning biomaterials in melanoma models, indicating improved localized drug delivery.

Key Points

To develop and evaluate injectable shear-thinning biomaterials for the localized, pH-responsive delivery of doxorubicin to treat melanoma.
Formulated injectable shear-thinning biomaterials capable of loading and stabilizing therapeutic molecules.
Evaluated the capacity of the biomaterial matrix for localized payload retention and environmental pH-triggered release.
Demonstrated efficient injectability and local depot retention characteristic of shear-thinning biomaterial matrices.
Achieved localized delivery of therapeutic agents designed to respond dynamically to acidic tumor microenvironments.

Cite This Study

Lee et al. (2021) studied this question.

synapsesocial.com/papers/6aa2d160a25963cecb13aab7 https://doi.org/10.1039/d1nr05738c

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Implication

Preclinical evaluation demonstrates pH-triggered doxorubicin release from shear-thinning biomaterials in melanoma models, indicating improved localized drug delivery.

pH-Responsive doxorubicin delivery using shear-thinning biomaterials for localized melanoma treatment

Discussion

Member takes

Implication

Key Points

Cite This Study

pH-Responsive doxorubicin delivery using shear-thinning biomaterials for localized melanoma treatment

Discussion

Member takes

Implication

Key Points

Cite This Study

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