Ex situ machine perfusion strategies in liver transplantation

This is the authors' abstract. We don't add key points for this paper.

A continuing discrepancy between organ availability and demand has forced utilization of extended criteria donor (ECD) livers, including donation after circulatory death, elderly or steatotic grafts, which are at increased risk of failure after transplantation. Especially for ECD grafts, dynamic preservation using ex situ machine perfusion (MP) allows reconditioning and viability assessment of livers prior to transplantation, rather than standard static cold storage (SCS) alone. MP is revolutionizing the field of liver transplantation and is undergoing rapid clinical implementation, albeit with several technical variations.