Walker 256 carcinoma was transplanted subcutaneously to 6-week-old male CD-COBS rats. Percutaneous diameters of the growing tumoral mass were measured daily. Groups of 4–10 animals selected at random were killed at established intervals, and tumoral tissue was isolated and weighed. Tumor weight was correlated with its percutaneous diameters. The overall growth of Walker 256 carcinoma was simulated by several mathematical models: linear approach, Gompertz equation, and a new model based on changes in blood supply to growing tumoral tissue were considered.
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Dagnino et al. (2009) studied this question.