Anti-Cephalothin Antibody and Coombs'-Positive Hemolytic Anemia

Letters1 January 1977Anti-Cephalothin Antibody and Coombs'-Positive Hemolytic AnemiaRONALD N. RUBIN, M.D., EDWARD R. BURKA, M.D.RONALD N. RUBIN, M.D., EDWARD R. BURKA, M.D.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-86-1-64 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptCephalothin therapy is associated with a positive direct antiglobulin test in 3% to 65% of patients receiving this drug (1, 2). Most often the responsible mechanism is nonimmune adsorption of serum proteins to cephalothin-exposed erythrocytes (3). Cephalothin-related hemolysis has been reported and is associated with specific anticephalothin antibodies (4, 5). We describe here a case of cephalothin-related Coombs' positive hemolytic anemia in which IgG antibody has been identified in the patient's serum and on erythrocytes.A 64-year-old white man was admitted to Thomas Jefferson University Hospital on 3 August 1975, for evaluation of chills...References1. MOLTHANREIDENBERGEICHMAN LMM: Positive direct Coombs tests due to cephalothin. N Engl J Med 277:123-125, 1967 CrossrefMedlineGoogle Scholar2. SPATHGARRATTYPETZ PGL: Studies on the immune response to penicillin and cephalothin in humans. II. Immunohematologic reactions to cephalothin administration. J Immunol 107:860-869, 1971 MedlineGoogle Scholar3. GARRATTYPETZ GL: Drug-induced hemolytic anemia. Am J Med 58:398-407, 1975 CrossrefMedlineGoogle Scholar4. GRALNICKMCGINNISSELTON HMW: Hemolytic anemia associated with cephalothin. JAMA 217:1193-1197, 1971 CrossrefMedlineGoogle Scholar5. JEANNETDAYERFARQUET MJJ: Cephalothin-induced immune hemolytic anemia. Acta Haematol (Basel) 55:109-117, 1976 CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: RONALD N. RUBIN, M.D.; EDWARD R. BURKA, M.D.Affiliations: Cardeza Foundation for Hematologic Research Thomas Jefferson University Hospital 1015 Walnut Street Philadelphia, PA 19107 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byCephalothin and CefazolinThe Changing Spectrum of Drug-Induced Immune Hemolytic AnemiaDrug-Induced Immune Hemolytic AnemiaReview: drug-induced immune hemolytic anemia—the last decadeSerology of antibodies to second- and third-generation cephalosporins associated with immune hemolytic anemia and/or positive direct antiglobulin testsCefotetan-induced immune hemolytic anemia due to the drug-adsorption mechanismImmune Cytopenia Associated With AntibioticsCephalosporin-induced hemolysis: A case report and review of the literatureDifferential stimulation of lymphocyte cell growth in vitro by cephalosporinsSuppression of Lymphocytes by CephalosporinsSuppression of lymphocyte responses by cephalosporinsPenicillins, cephalosporins and tetracyclines 1 January 1977Volume 86, Issue 1Page: 64-65KeywordsAntibody therapyDrug therapyHemolytic anemiaSerum proteins ePublished: 1 December 2008 Issue Published: 1 January 1977 PDF downloadLoading ...