Aim: A treatment of extensive burn contracture in children needs to repeat the autologous skin graft. This study was designed to evaluate the application of autologous CDS to prepare the proper wound bed acceptable for the split‐thickness autologous skin graft. Methods: Prior to the clinical study, the master cell banking system was established using a small piece of skin derived from each patient. The autologous CDS was prepared by plating the patient's own fibroblasts, cultured from the master cells, on a spongy matrix of hyaluronic acid and atelo‐collagen. The CDS was applied on the skin defects left behind surgical excision to release scar contracture. The split‐thickness autologous skin graft (6∼8/1000 inch) was applied on the wound bed, prepared by using the CDS. Results: The clinical trials were conducted in 5 cases. When the autologous CDS was applied on the skin defect, exposing subcutaneous fatty tissue, the highly vascularlized wound bed was prepared within about 1 week. Although a split‐thickness skin graft was very thin, the severe contracture was not observed over a period of several months. Conclusion: The application of autologous CDS is promising for the treatment for extensive burn scar contracture in children.
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Fujimori et al. (2004) studied this question.