Induction of Experimental Tromboses in Animal Model

Introduction: In vivo studies, related to thrombosis, allow a better understanding of the biological behavior of molecules with thrombolytic properties. Goal: To evaluate the methodological characteristics as well as the efficacy of thrombosis induced by the association of the blood stasis method and ferric chloride (FeCl3). Methodology: Review of published literature on the topic “Experimental thrombosis”. This search was performed in the Pubmed, ScieceDirect, Scielo and Google Academic databases, by crossing the following descriptors: Thrombosis, Fibrinolytics and Cardiovascular Diseases. Articles, dissertations and theses written in Portuguese and English were selected without delimitation of the date of publication. Results: National and international studies have shown that the induction of thrombosis, by association of the methods mentioned above, is simple, cheap and reproducible. In addition, this combination of techniques allows adequate mimicking of the thrombogenic characteristics observed in humans. Conclusion: Studies in biological models are essential for understanding the mechanisms involved in thrombotic disorders.