21,21,21-Trifluoro(aryl)thevinols were synthesized by the reaction of 21,21,21-trifluorothevinone with aryl Grignard reagents. The absolute configuration at C 20 atom in these CF 3 -substituted alcohols can be easily determined by one-dimensional 19 F NMR spectroscopy that was verified by X-ray diffraction studies.
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Zelentsova et al. (2022) studied this question.
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