Identified 15 years ago, the Wld mouse carries a spontaneous mutation that encodes a fusion protein with neuroprotective properties. In a Perspective, [Simon][1] discusses new work ([ Araki et al .][2]) that identifies the Nmnat1 fragment of the fusion protein as mediating neuroprotection by boosting NAD biosynthesis and increasing the activity of the NAD-dependent deacetylase, SIRT1, a regulator of transcription. [1]: http://www.sciencemag.org/cgi/content/full/305/5686/954 [2]: http://www.sciencemag.org/cgi/content/full/305/5686/1010
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Bedalov et al. (2004) studied this question.
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