Combined central nervous system tuberculosis and neurocryptococcosis in a non-HIV patient following severe psychological trauma

Simultaneous CNS tuberculosis and neuro cryptococcosis are rare in immunocompromised patients and more rare in immune-competent patients, immunosuppression by HIV infection is the main contributing factor, herein, we describe a case of CNS tuberculosis with cryptococcal meningitis after a long period of severe psychological stress alternating with anxiety and depression, the purpose is to highlight the effect of stress on the immune system and the consequent exposure to severe infection.