Preparation of Hydroxypropyl‐β‐cyclodextrin Cross‐linked Multi‐walled Carbon Nanotubes and Their Application in Enantioseparation of Clenbuterol

A method of cross‐linking multi‐walled carbon nanotubes by a nucleophilic substitution of brominated multi‐walled carbon nanotubes using hydroxypropyl‐β‐cyclodextrin anions was studied. The modified multi‐walled carbon nanotube samples were characterized using thermogravimetric analysis, energy‐dispersive X‐ray spectroscopy, transmission electron microscopy, scanning electron microscopy, Raman spectroscopy and Fourier transform infrared spectroscopy. The hydroxypropyl‐β‐cyclodextrin modified multi‐walled carbon nanotubes were used as a chiral stationary phase additive for thin‐layer chromatography to separate clenbuterol enantiomers, and the chiral separation factor was increased.