SummaryThe daily dosage requirement of 9 alpha chlorohydrocortisone acetate to permit survival of adrenalectomized rats for 20 days indicates that this compound is 10 times more active than cortisone acetate. Activity was equal to or slightly greater than desoxycorticosterone acetate. A single injection of chloro-F-acetate (.25 mg) provided a longer survival of adrenalectomized rats than cortisone acetate (205 mg). Hormone effectiveness was influenced by diet.
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Leathem et al. (1954) studied this question.