Key result
Comparing global mRNA expression at the aneurysm rupture edge to the anterior sac identified apoptosis, angiogenesis, and inflammation as potentially important participants in aneurysm rupture.
Observational
No change to aneurysm management warranted; leaves open mechanistic validation and therapeutic targeting of rupture pathways.
To search for novel transcriptional pathways that are activated in abdominal aortic aneurysm rupture, cDNA microarrays were used to compare global mRNA expression at the aneurysm rupture edge to anterior sac, and selected results were confirmed using quantitative real-time-polymerase chain reaction (QRT-PCR). This study identified apoptosis, angiogenesis, and inflammation as potentially important participants during the process of aneurysm rupture.
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Choke et al. (2006) conducted an observational in Abdominal aortic aneurysm rupture. Aneurysm rupture edge tissue vs. Anterior sac tissue was evaluated on Global mRNA expression (transcriptional pathways). Comparing global mRNA expression at the aneurysm rupture edge to the anterior sac identified apoptosis, angiogenesis, and inflammation as potentially important participants in aneurysm rupture.
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