Key result
Taking antihypertensive drugs was associated with 13.4 mmHg lower systolic blood pressure and 7.8 mmHg lower diastolic blood pressure.
Why the study?
Hypertension is widely prevalent with high costs, necessitating precise knowledge of BP distributions and factors affecting BP.
Observational (n=12,877,653)
Effect estimate: 13.4 mmHg lower SBP and 7.8 mmHg lower DBP
In a large-scale Japanese medical checkup dataset, average blood pressure was 120.4/74.2 mmHg, with age, gender, and obesity identified as significant factors affecting blood pressure levels.
Background: The high blood pressure (BP) or hypertension is a widely prevalent disease and its costs are very high, and many studies about the relationships between BP and health conditions have been done. We need to know the precise distributions of BP and factors affecting BP. Data and Methods: The distributions of BP are analyzed using 12,877,653 observations obtained from the JMDC Claims Database. The factors that may affect the BP are analyzed by the regression models using 4,615,346 observations. Results: The averages of systolic BP (SBP) and diastolic BP (DBP) are 120.4 and 74.2 mmHg with standard deviations of 15.9 and 11.3 mmHg, respectively. Among the nonmodifiable factors, age and gender are important factors. Among the modifiable factors, variables related to obesity are important risk factors. Taking antihypertensive drugs makes SBP and DBP 13.4 mmHg and 7.8 mmHg lower. Conclusion: The criteria of BP should be carefully determined considering age and gender. The effects of age may be a little different for SBP and DBP. It is necessary to use the proper model to evaluate the effect of antihypertensive drugs correctly. Limitations: The dataset is observatory. Although there are various types of treatment methods and antihypertension drugs, their effects are not evaluated.
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Kazumitsu Nawata (2021) conducted an observational in Hypertension (n=12,877,653). Antihypertensive drugs was evaluated on Systolic and diastolic blood pressure (13.4 mmHg lower SBP and 7.8 mmHg lower DBP). Taking antihypertensive drugs was associated with 13.4 mmHg lower systolic blood pressure and 7.8 mmHg lower diastolic blood pressure.
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