Key result
Younger patients (<50 years) with LMCA disease had similar clinical signs to older patients, but higher rates of tobacco use (79% vs 39%, P<0.001) and less diabetes (10% vs 34%, P=0.028).
Why the study?
Do clinical signs, symptoms, and risk factors of left main coronary artery disease vary between younger (<50 years) and older patients?
Observational (n=100)
Do clinical signs, symptoms, and risk factors of left main coronary artery disease vary between younger (<50 years) and older patients?
In patients with significant left main coronary artery disease, younger patients (<50 years) present with similar clinical signs and symptoms as older patients but have a distinct risk factor profile characterized by higher tobacco use and lower rates of diabetes and hypertension.
Answers are grounded in this paper and cite their sources.
May warrant tobacco screening in younger LMCA patients despite similar presentations; hypothesis-generating for age-specific prevention trials.
Left main coronary artery (LMCA) disease is a potentially lethal disease that can be effectively treated if it is recognized expeditiously. To determine whether clinical signs and symptoms vary with age, we examined data from 100 patients with angiographically significant LMCA disease (> or =50% stenosis). The majority of patients had myocardial infarction (32%) or Braunwald class I unstable angina (46%). There were no differences in initial symptoms, electrocardiographic findings (normal or only nonspecific changes in 52% of patients), or left ventricular function (normal or only mildly impaired in 76% of patients) between younger patients (< 50 yr; n = 29) and older patients (n = 71). Severe atherosclerosis was common in both groups. Risk factor profiles were different, however, in that diabetes mellitus (10% vs. 34%; P = 0.028) and hypertension (38% vs. 73%; P = 0.002) were less common and tobacco use was more common (79% vs. 39%; P <0.001) in younger patients. In summary, age influenced the risk factors associated with but not the clinical signs and symptoms of LMCAD.
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Stouffer et al. (2000) conducted an observational in Left main coronary artery (LMCA) disease (n=100). Younger age (< 50 years) vs. Older patients was evaluated on Clinical signs, symptoms, and risk factor profiles. Younger patients (<50 years) with LMCA disease had similar clinical signs to older patients, but higher rates of tobacco use (79% vs 39%, P<0.001) and less diabetes (10% vs 34%, P=0.028).
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