Key result
Metabolic fat obesity in young asthmatics is linked to adipokine and carbohydrate disorders versus healthy obesity.
Why the study?
Understanding combinations of bronchial asthma and obesity phenotypes may enable differentiated treatment, while clinical and laboratory features remain to be evaluated in young patients to optimize therapy and early diagnosis of cardiovascular complications.
Does epicardial adipose tissue thickness measured by echocardiography predict metabolic fat obesity phenotype in young patients with bronchial asthma?
Observational (n=204)
Does epicardial adipose tissue thickness measured by echocardiography predict metabolic fat obesity phenotype in young patients with bronchial asthma?
Epicardial adipose tissue thickness measured by echocardiography may serve as a predictor of adverse metabolic obesity phenotypes and cardiovascular risk in young patients with bronchial asthma.
May signal higher cardiometabolic risk in young asthma patients with unhealthy obesity; hypothesis-generating for epicardial fat prediction.
One of the directions in the study of diseases is their phenotyping. Thus, understanding the peculiarities of bronchial asthma (BA) and various types of obesity phenotypes combination will not only provide a differentiated approach to treatment, but also achieve maximum therapeutic effect. The aim of this study was to evaluate clinical and laboratory features of various obesity phenotypes in BA patients at a young age in order to optimize antiasthmatic therapy and early diagnosis of cardiovascular complications. Methods . Patients with BA of different severity were examined (n = 164); the control group was made up of relatively healthy subjects (n = 40). The subjects were divided into groups with BMI (Body Mass Index); the 1 st group (n = 93) included patients with BMI 18.5–24.9 kg/m 2 ; the 2 nd group (n = 80) included BA patients with BMI 30–34.9 kg/m 2 (1st degree obesity). Overweight patients were detected, clinical and functional examination was performed, epicardial adipose tissue thickness (EATT) was measured by standard two-dimensional echocardiography (EchoCG), obesity degree, cytokine, adipokine, insulin levels, insulin resistance indices were determined. Results . According to the results of the study in patients with BA and metabolic fat obesity phenotype (MFOP) a significant disorder of adipokine balance was revealed, carbohydrate metabolism disorder was noted, and significantly higher insulin levels were observed, insulin resistance index (Homeostasis Model Assessment of Insulin Resistance – НОМА-IR) and decrease in insulin sensitivity index (ISI) relative to the group of patients with metabolically healthy obesity phenotype and control. Conclusion . It has been established that the EATT determined by the EchoCG method can serve as a predictor of MFOP and a risk factor for cardiovascular diseases.
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Soloveva et al. (2020) conducted an observational in Bronchial asthma and obesity (n=204). Metabolic fat obesity phenotype vs. Metabolically healthy obesity phenotype and healthy controls was evaluated on Adipokine balance, carbohydrate metabolism, and insulin resistance. In young patients with bronchial asthma, the metabolic fat obesity phenotype was associated with significant adipokine and carbohydrate metabolism disorders compared to metabolically healthy obesity.
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