Key result
TGF-β2 rs6658835 G allele linked to ~65% higher odds of conotruncal heart defects.
Why the study?
Is there an association between TGF-β2 gene polymorphisms and the risk of conotruncal heart defects?
Case-Control (n=569)
Is there an association between TGF-β2 gene polymorphisms and the risk of conotruncal heart defects?
Odds Ratio: 1.649
Absolute Event Rate: 52.7% vs 40.3%
p-value: p=<0.001
The TGF-β2 gene polymorphism rs6658835 is associated with an increased risk of conotruncal heart defects, suggesting its potential as a genetic marker.
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Hypothesis-generating for TGF-β2 rs6658835 as risk marker; does not support clinical genetic testing for conotruncal defects.
Chen et al. (2016) conducted a case-control in Conotruncal heart defects (n=569). TGF-β2 gene polymorphisms (SNP rs6658835 and rs10495098) vs. Control subjects was evaluated on Frequency of G allele (SNP rs6658835) (OR 1.649, p=<0.001). The G allele of SNP rs6658835 in the TGF-β2 gene was significantly associated with conotruncal heart defects compared to controls (52.7% vs 40.3%; OR 1.649; p<0.001).
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