Pressure-stable adsorbents for the direct HPLC separation of numerous racemic drugs are obtained by polymerization of the monomers 1 in the presence of acryloyl- or diolsubstituted silica gel. Optically active poly-acrylamides and polymethacrylamides that are not bound to silica gel have already proven useful in low-pressure chromatography.
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Blaschke et al. (1986) studied this question.
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