Key result
Statin therapy for more than 7 days was significantly associated with reduced 28-day mortality (OR 0.47) compared to no statin therapy in adult patients with sepsis.
Why the study?
It remains controversial whether statin therapy is beneficial for sepsis patients.
Does statin therapy reduce 28-day mortality in adult sepsis patients?
Cohort (n=21,320)
No
Does statin therapy reduce 28-day mortality in adult sepsis patients?
Odds Ratio: 0.47 (95% CI 0.37–0.6)
Absolute Event Rate: 12.4% vs 18.1%
p-value: p=<0.001
In a large retrospective cohort of ICU patients with sepsis, statin therapy for more than 7 days was associated with significantly reduced 28-day and 90-day mortality.
Statin use was associated with lower sepsis mortality; leaves open whether RCTs should test this before any practice change.
BackgroundIt is controversial whether statin therapy is beneficial for sepsis patients. A large retrospective cohort study was conducted to evaluate the association between statin therapy and mortality in sepsis patients.MethodsAdult (≥18 years) sepsis patients were enrolled and divided into two groups: the statin group and the no-statin group. Data including demographic features, vital signs, laboratory tests, and comorbidities from MIMIC-IV v1.0 were extracted. Delirium was assessed via the Confusion Assessment Method for the ICU (CAM-ICU). Ninety-day mortality, 28-day mortality and the incidence of delirium after statin therapy were evaluated using multivariable logistic analysis, the PSM model and subgroup analysis based on univariate analysis. ResultsIn univariate analysis and multivariable logistic analysis, statin therapy showed a significant association with both reduced 28-day and 90-day mortality (90-day mortality: OR 0.58, 95% CI: 0.46-0.72, p<0.001; 28-day mortality: OR 0.47, 95% CI: 0.37-0.60, p<0.001), while no relationship was found between statin therapy and delirium (OR 0.92, 95% CI: 0.49-1.72, p=0.787). In further PSM model and subgroup analyses or sensitivity analysis, consistent results were shown. ConclusionStatin therapy is significantly associated with 28-day and 90-day mortality without decrease in the incidence of delirium.
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Shi et al. (2021) conducted a cohort in Sepsis (n=21,320). Statin therapy vs. No statin therapy or statin therapy for less than 7 days was evaluated on 28-day mortality (OR 0.47, 95% CI 0.37-0.60, p=<0.001). Statin therapy for more than 7 days was significantly associated with reduced 28-day mortality (OR 0.47) compared to no statin therapy in adult patients with sepsis.
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