Key result
Low-dose ropivacaine and sufentanil epidural provides labor analgesia in a pregnant SCN5A gene mutation carrier.
Case Report (n=1)
Low dose ropivacaine and sufentanil can be considered for epidural analgesia during labour in patients with SCN5A gene mutations.
May support low-dose epidural in SCN5A pregnancies; leaves open broader safety pending controlled data.
SCN5A gene mutations can lead to ion channel defects which can cause cardiac conduction disturbances. In the presence of specific ECG characteristics, this mutation is called Brugada syndrome. Many drugs are associated with adverse events, making anesthesia in patients with SCN5A gene mutations or Brugada syndrome challenging. In this case report, we describe a pregnant patient with this mutation who received epidural analgesia using low dose ropivacaine and sufentanil during labour.
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Dortmont et al. (2016) conducted a case report in SCN5A gene mutation (n=1). Epidural analgesia with ropivacaine and sufentanil was evaluated. Epidural analgesia using low dose ropivacaine and sufentanil was administered during labour in a pregnant patient with an SCN5A gene mutation.
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