Key result
Fibroblast DHP-sensitive Ca2+ channel density varies with growth conditions, implying involvement in proliferation control.
Population
Cultured human embryonic fibroblasts
Comparison
Radioactively labeled 1,4-dihydropyridine probe… vs Different growth conditions
Design
Preclinical
Authors
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No immediate clinical implications from cultured fibroblasts; leaves open a regulatory role for DHP-sensitive Ca2+ channels in human cell proliferation.
DHP-sensitive Ca2+ channels are present in human embryonic fibroblasts and their density varies with growth conditions, suggesting involvement in cell proliferation control.
Dudkin et al. (1988) studied this question. Cell culture conditions (serum vs serum-free) was evaluated on 1,4-dihydropyridine (DHP) binding sites (Bmax and Kd). Cultured human embryonic fibroblasts contain DHP-sensitive Ca2+ channels whose binding site density varies with cell density and serum presence, implying involvement in proliferation control.
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