Key result
Neurodegenerative diseases were associated with a significantly higher risk of pneumonia compared to individuals without neurodegenerative diseases (aHR 2.10; 95% CI 1.96-2.24).
Why the study?
The association between pneumonia and neurodegenerative diseases had never been reported in detail relative to the general population.
Do neurodegenerative diseases increase the risk of pneumonia in the general population?
Cohort (n=95,289)
Do neurodegenerative diseases increase the risk of pneumonia in the general population?
Hazard Ratio: 2.1 (95% CI 1.96–2.24)
Patients with neurodegenerative diseases have a significantly higher risk of developing pneumonia compared to the general population, particularly among the elderly and men.
May support heightened pneumonia vigilance in neurodegenerative disease; leaves open causality and preventive intervention effects.
PURPOSE: The association between pneumonia and neurodegenerative diseases (NDs) has never been reported in detail. We address this relationship with reference to the general population. METHODS: Using Taiwan's National Health Insurance Research Database to identify a pneumonia cohort (including the typical and atypical), we established an ND cohort of 19,062 patients and a non-ND cohort of 76,227 people. In both cohorts, the risk of pneumonia was measured using multivariable Cox proportional hazards models. RESULTS: The adjusted hazard ratio (aHR) (95% confidence interval [CI]) for the pneumonia cohort was 2.10 (1.96-2.24), regardless of age, sex, comorbidities or drug use in the ND cohort. The aHR (95% CI) for adults aged 20-49 years was 2.08 (1.58-2.75), men 2.20 (2.01-2.40). However, older subjects were at greatest risk of pneumonia, (3.41 [2.99-3.88]) if the 20-49 years age group is used as the reference. For the ND and non-ND cohorts, those with comorbidities (with the exception of hyperlipidemia) had higher risk; aHR (95% CI) 2.35 (2.30-2.52). The aHR (95% CI) for those without comorbidities is 3.28 (2.52-4.26). No significant difference was observed in incidence of pneumonia between those who were and were not using statin medications; the aHR (95% CI) was 1.03 (0.93-1.14). CONCLUSION: The ND cohort had a higher risk of pneumonia, regardless of age, sex, comorbidities or statin use. The risk of pneumonia was higher in elderly and male patients in the ND cohort.
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Yeh et al. (2018) conducted a cohort in Neurodegenerative diseases (n=95,289). Neurodegenerative diseases vs. No neurodegenerative diseases was evaluated on Pneumonia (aHR 2.10, 95% CI 1.96-2.24). Neurodegenerative diseases were associated with a significantly higher risk of pneumonia compared to individuals without neurodegenerative diseases (aHR 2.10; 95% CI 1.96-2.24).
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