Key result
MiRNAs modulate cardiac development, cell cycle, inflammation, and apoptosis, presenting potential diagnostic and therapeutic targets for cardiac and mediastinal tumors.
Why the study?
Dysfunctions in miRNA production have recently been investigated as predictors of neoplasms and therapeutic strategies, prompting a summary of available knowledge in cardiac and mediastinal tumors.
A deep understanding of miRNAs could revolutionize the diagnostics and prevention of cardiac and mediastinal tumors in cardio-oncology.
MiRNA targeting in cardiac tumors should not yet alter practice; leaves open translation from modulation data to clinical benefit.
Dysfunctions in miRNA production have been recently investigated as predictors of neoplasms and their therapeutic strategies. In this review, we summarize the available knowledge on miRNAs and cardiac tumors (such as myxoma) and mediastinal tumors (such as thymoma) and propose new avenues for future research. MiRNAs are crucial for cardiac development through the expression of cardiac transcription factors (miR-335-5p), hinder the cell cycle by modulating the activity of transcription factors (miR-126-3p, miR-320a), modulate the production of inflammatory factors such as interleukins (miR-217), and interfere with cell proliferation or apoptosis (miR-218, miR-634 and miR-122). Current and future research on miRNAs is essential, as a deep understanding could lead to a revolution in the field of diagnostics and prevention of neoplastic diseases.
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Loreni et al. (2024) conducted a review in Cardiac and mediastinal tumors. miRNAs was evaluated. MiRNAs modulate cardiac development, cell cycle, inflammation, and apoptosis, presenting potential diagnostic and therapeutic targets for cardiac and mediastinal tumors.
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