May 1, 1990Pacing and Clinical Electrophysiology
Therapy Assessment for Sustained Ventricular Tachyarrhythmias: How Many Electropharmacological Tests are Appropriate?
Key result
Serial EP testing achieves VT suppression in 70% of patients regardless of prior unsuccessful tests.
- n=94
Why the study?
Does serial electropharmacological testing improve suppression of VT inducibility in patients with inducible sustained ventricular tachyarrhythmias?
Population
94 patients with inducible sustained ventricular tachyarrhythmias (VT)
Design
Cohort
Follow-up
34 +/- 11 months
Authors
Discussion
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Member takes
Implication
May support extended serial EP testing in selected VT patients; leaves open whether it improves outcomes versus nonpharmacological options.
Study Design
Type
Cohort (n=94)
Structured PICO
Does serial electropharmacological testing improve suppression of VT inducibility in patients with inducible sustained ventricular tachyarrhythmias?
P
Population
94 patients with inducible sustained ventricular tachyarrhythmias undergoing serial electropharmacological tests, followed for a mean of 34 months.
E
Exposure
Serial electropharmacological (EP) tests with antiarrhythmic drugs (up to 11 tests per patient)
O
Outcome
Suppression of VT inducibilitysurrogate
Extensive serial electropharmacological testing may be worthwhile in selected patients with sustained VT, as effective antiarrhythmic drugs can still be identified even after multiple failed tests.
Cite This Study
Schoels et al. (1990) conducted a cohort in inducible sustained ventricular tachyarrhythmias (n=94). Serial electropharmacological (EP) tests was evaluated on suppression of VT inducibility. Serial electropharmacological testing achieved suppression of ventricular tachycardia inducibility in 70% of patients, with no critical number of unsuccessful tests separating responders.