Key result
Glycoconjugates such as glycoproteins and glycolipids, particularly within lipid rafts, play essential roles in neuronal signal transduction and are implicated in the pathogenesis of neurological disorders.
Provides an overview of the role of glycobiology, including glycoproteins and glycolipids, in normal neuronal biology and neurological disorders such as Alzheimer's disease.
Glycoconjugates merit targeted neurological research; leaves open any clinical role pending interventional trials.
Many researchers now recognize the importance of glycobiological research achievements. Glycoside-containing substances such as proteins (glycoproteins) and lipids (glycosphingolipids) have been involved in many important and essential events for normal life. The production of glycoside residues of the proteins is only partially regulated by the genes. In this talk, I will make a brief description of what glycobiology can influence the future of neurological research arena and how glycoproteins and glycolipids affect the normal biology of the neurons. Furthermore, I will introduce you some evidences that many neurological disorders such as Alzheimer's disease and immune-mediated encephalitis have special relationships with glycobiological abnormalities. I also explain the structures and functions of lipid rafts, caveolae, and glycosynapse and their roles in the intracellular signal transduction and cell motility.
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Tatsuro Mutoh (2011) conducted a review in Neurological disorders. Glycoconjugates such as glycoproteins and glycolipids, particularly within lipid rafts, play essential roles in neuronal signal transduction and are implicated in the pathogenesis of neurological disorders.
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