Key result
Caffeine (7.5 mg/kg) restored myocardial cytochrome oxidase activity, increased cardiac function, and significantly improved survival compared with saline in a rat model of sepsis.
Why the study?
Does caffeine improve myocardial cytochrome oxidase activity, cardiac function, and survival in a rat model of sepsis?
RCT (n=120)
randomized
No
Does caffeine improve myocardial cytochrome oxidase activity, cardiac function, and survival in a rat model of sepsis?
Caffeine administration restored myocardial cytochrome oxidase activity, improved cardiac function, and increased survival in a rat model of sepsis-associated myocardial depression.
No takes yet. Share an insight, caveat, or question.
Caffeine benefits septic rats; hypothesis-generating and leaves open translation to human sepsis care.
Verma et al. (2009) conducted an RCT in Sepsis-associated myocardial depression (n=120). Caffeine vs. Saline was evaluated on Myocardial cytochrome oxidase (CcOX) activity, cardiac function, and survival. Caffeine (7.5 mg/kg) restored myocardial cytochrome oxidase activity, increased cardiac function, and significantly improved survival compared with saline in a rat model of sepsis.
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