Key result
Hypoxic training boosts muscle BAIBA ~121% and increases white fat browning markers in obese rats.
Why the study?
Obesity is a major health risk factor, and the effects of hypoxic training on BAIBA secretion and white fat browning in obese models required exploration.
Does hypoxic training improve white fat browning and lipid profiles in obese rats?
Does hypoxic training improve white fat browning and lipid profiles in obese rats?
Absolute Event Rate: 3.72% vs 1.68%
p-value: p=<0.01
Hypoxic training may improve blood lipid profiles and promote white fat browning in obese rats by modulating BAIBA, PPARα, and UCP-1 expression.
Hypoxic training effects on BAIBA and fat browning remain preclinical; hypothesis-generating for human obesity trials.
In recent years, obesity has become an important risk factor for human health; how to effectively prevent and reduce the occurrence of obesity is a hot research topic in recent years. Hypoxic training effectively improves abnormalities of lipid metabolism caused by obesity. The current study explored the effects of hypoxic training on BAIBA secretion and white fat browning in inguinal fat in obese rats. Analyses were performed by HPLC/MS/MS-MS/MS, RT-q PCR and western blot methods. The findings showed that 4 weeks of hypoxic training reduced body weight, Lee's index, and regulated blood lipid profile in obese rats. Hypoxic training up-regulated BAIBA concentration in gastrocnemius muscle and circulation in obese rats. Hypoxic training significantly upregulated expression of PPARα and UCP-1 in inguinal fat of obese rats and increased white fat browning. The findings showed that BAIBA may involve in improveing blood lipid profile and white fat browning by modulating PPARα and UCP-1 expression.
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Feng et al. (2022) studied Obesity (n=48). Hypoxic training vs. Normoxic control, normoxic exercise, and hypoxic control was evaluated on Muscle BAIBA concentration (ng/mg) (p=<0.01). Four weeks of hypoxic training significantly upregulated BAIBA concentration in gastrocnemius muscle and increased white fat browning markers PPARα and UCP-1 in obese rats.
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