Proper placentation is required for a successful pregnancy outcome and depends on proper trophoblast cell differentiation. Thromboinflammation‚ likely due to platelet activation and other proinflammatory mediators, causes defective syncytiotrophoblast differentiation and placental dysfunction, with preeclampsia. Platelet parameters and specific biomarkers are risk indicators in preeclampsia, useful in monitoring and establishing preventive treatment. Research is ongoing to further elucidate the pathophysiological pathways involved in preeclampsia, which could lead to improved management strategies for afflicted patients and will be used to identify new therapeutic targets to manage or prevent this condition.
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Cionca et al. (2024) studied this question.
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