Key result
Lisinopril prevented iron deposition in the proximal renal tubules of Tsukuba hypertensive mice, whereas deposition was observed in the control and hydralazine groups.
Why the study?
Does lisinopril prevent deposition of iron in renal tissue in Tsukuba hypertensive mice?
Does lisinopril prevent deposition of iron in renal tissue in Tsukuba hypertensive mice?
Lisinopril prevents iron deposition in the proximal renal tubules of hypertensive mice overexpressing the human renin-angiotensin system, an effect independent of blood pressure reduction.
Does not support clinical use of ACE inhibitors to prevent renal iron deposition; leaves open RAS-specific effects in hypertensive models.
SUMMARY: Tsukuba hypertensive mice (THM) are transgenic mice that carry both human renin and angiotensinogen genes and overexpress the human renin‐angiotensin system (RAS). In the present study, the effect of lisinopril on deposition of macromolecular iron in renal tissue in THM was evaluated. Twelve‐week‐old male THM were divided into the following groups: lisinopril dosage group (ACEI group), hydralazine dosage group (hydralazine group), and a no‐drug group (control group). Age‐matched male C57BL/6 mice (wild group) were used as normal controls. Each mouse was treated with a drug for 8 weeks. All mice were euthanised at 20 weeks of age, and their kidneys were fixed and stained with Berlin‐blue. Systolic blood pressure was significantly higher in the control group than in the wild group, and it decreased significantly to similar levels in the ACEI group and the hydralazine group. Iron deposition was observed in proximal renal tubules in the control group and the hydralazine group, but iron deposition was not observed in the ACEI group or the wild group. The results of the study suggest that the RAS plays an important role in the deposition of iron in the proximal renal tubules in THM, and that lisinopril prevents this deposition.
No takes yet. Share an insight, caveat, or question.
Kai et al. (2000) studied Hypertension and renal iron deposition. Lisinopril vs. Hydralazine, no-drug control, and wild-type mice was evaluated on Deposition of macromolecular iron in renal tissue. Lisinopril prevented iron deposition in the proximal renal tubules of Tsukuba hypertensive mice, whereas deposition was observed in the control and hydralazine groups.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: