Biological Antagonism: The Theory of Biological Relativity.

This volume is a well-organized summary of the efforts that have been expended and the results that have been obtained in the field of biological antagonism. The author has chosen to compile this summary of the concept of metabolite analogue displacement because he believes "... that in no single instance of specific displacement has a thorough job been done, and that such work, properly undertaken, will lead to discoveries of chemotherapeutic agents of great value in medical science." This book consists of 22 chapters, most of which are concerned with individual compounds or groups of compounds that are of biological importance. Seven of the chapters are on biological antagonism in protein and amino acids and six on antimetabolites of vitamins. Single chapters deal with the antagonists of purines and pyrimidines, steroids and lipids, ionic and inorganic compounds, and miscellaneous information. Other general subjects, such as enzymatic inhibition, drug resistance, biological relativity,