Polyzwitterionic biomaterial with pH-responsive and hemocompatible dual functions is formulated by the copolymerization of 2-(N, N-dimethyl amino) ethyl methacrylate (DMAEMA) sequences and sulfobetaine methacrylate (SBMA) moieties. Hydrogels are salt responsive, due to the interplay between hydrogen bonds formation, ions solvation, and antipolyelectrolyte effect, while DMAEMA sequences provide pH-responsiveness. Their low-fouling nature is demonstrated using plasma proteins and bacteria. Improved hemocompatibility with SBMA content is unveiled by the resistance to platelet and erythrocyte attachment, as well as from delayed plasma clotting time. Overall, this study suggests that dual-functional zwitterionic hydrogels are promising pH-responsive and hemocompatible polymeric biomaterials.
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Venault et al. (2015) studied this question.
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