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Ganglioside GTlb inactivated botulinum toxins. The inactivation of type A, B, E and F toxins was marked but that of type C and D was less. Inactivation of type A toxin by ganglioside was significantly inhibited by one of two toxin fragments. The inactivation of botulinum toxin with ganglioside GTlb was affected by the ionic strength of the solvent. The findings indicate that ganglioside GTlb may not be implicated in the primary binding site for botulinum toxins on the synaptic membrane.
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Kozaki et al. (1984) studied this question.
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