Why the study?
Idiopathic pulmonary fibrosis has high mortality and limited treatments, prompting exploration of cuproptosis- and immune-related hub genes as potential diagnostic biomarkers and therapeutic targets.
Population
Four microarray datasets from the Gene Expression Omnibus (GEO) collection for IPF
Design
Bioinformatics and single-cell RNA-seq analysis
Key result
Cuproptosis-related gene NUDT16 and immune-related gene CXCL12 demonstrated exceptional diagnostic performance for idiopathic pulmonary fibrosis, each achieving an AUROC of 0.92.
Authors
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Hypothesis-generating for IPF biomarkers; requires prospective validation before any diagnostic use.
Observational (n=303)
Effect estimate: AUROC 0.92 (95% CI 0.86-0.98)
Bioinformatics analysis identified five cuproptosis-related and four immune-related hub genes as potential diagnostic biomarkers and therapeutic targets for idiopathic pulmonary fibrosis.
Jin et al. (2025) conducted an observational in Idiopathic pulmonary fibrosis (IPF) (n=303). Cuproptosis and immune-related gene expression vs. Healthy controls was evaluated on Diagnostic accuracy (AUROC) for idiopathic pulmonary fibrosis (AUROC 0.92, 95% CI 0.86-0.98). Cuproptosis-related gene NUDT16 and immune-related gene CXCL12 demonstrated exceptional diagnostic performance for idiopathic pulmonary fibrosis, each achieving an AUROC of 0.92.