Reversible language regression as an adverse effect of topiramate treatment in children

1057 Objectives: We explored whether the feature of the additionally found radiotracer uptake on breast-specific gamma imaging (BSGI) was associated with malignancy. Methods: Data on breast cancer patients who underwent preoperative BSGI, mammography, and breast ultrasonography were retrospectively reviewed. In addition to BSGI uptake features known to reflect previously diagnosed malignancies, additional lesions evident on BSGI were correlated with histological and clinical follow-up data obtained over at least 6 months. BSGI uptake was divided into one of three categories: focus-foci, mass, or non-mass. The morphological descriptors for foci were their numbers (solitary or multifocal) and intensity (mild, moderate, or intense). The descriptors for mass lesions were shape (oval, round, lobulated, or irregular) and intensity (mild, moderate, or intense). The morphological descriptors for non-mass lesions were distribution (focal, regional, linear/ductal, segmental, or diffuse) and intensity (mild, moderate, or intense). Results: Of a total of 391 breast lesions from 236 patients, 242 malignancies had been identified prior to BSGI and 149 additional lesions were found on BSGI. Of these additional lesions, the final diagnoses were malignancy in 40 (27%) and benign in 109 (73%). The malignancy rates of mass and non-mass lesions, and foci were 60% (15/25), 19% (14/85), and 30% (6/20). Of 19 lesions lacking discernible uptake, 5 (26%) were malignant. Mass lesions that were lobulated or irregular in shape were more often malignant than those that were oval or round (P = 0.005). Non-mass lesions exhibiting focal or linear/ductal uptake patterns on BSGI were more often malignant than those exhibiting regional or segmental patterns (P < 0.001). We found no associations between the intensities of additional mass, non-mass lesions or foci, and malignancy. Conclusion: Analysis of shape and distribution of radiotracer uptake in BSGI is useful in predicting whether breast lesions found additionally on BSGI are malignant. Research Support: No