Key result
Treatment of neonatal rat cardiac myocytes with IL-1 beta caused a rapid and transient depletion of I kappa B-alpha, reducing to 16% of initial levels within 5 minutes.
Population
Human and rat myocardial samples at various developmental stages, and neonatal rat cardiac myocytes in vitro
Comparison
Interleukin-1 beta 5 ng/ml for 0-60 minutes vs Untreated baseline (0 min)
Design
Preclinical
Follow-up
60 minutes
Authors
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Rapid IκB-α depletion by IL-1β in rat myocytes is hypothesis-generating; leaves open NF-κB activation in human myocardial cytokine responses.
NF-kappa B subunits are present throughout myocardial development and are activated by IL-1 beta, suggesting a role in gene regulation in response to cytokines in cardiac myocytes.
David A.M. Norman (1998) studied Myocardial development. Interleukin-1 beta (IL-1 beta) was evaluated on Depletion of I kappa B-alpha and I kappa B-beta. Treatment of neonatal rat cardiac myocytes with IL-1 beta caused a rapid and transient depletion of I kappa B-alpha, reducing to 16% of initial levels within 5 minutes.
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