Key result
A composition containing phosphonoacetic acid showed antiviral effects against herpes simplex virus 1 and 2 and cytomegalovirus without cytotoxic effects on VERO and M-19 cell cultures.
A newly synthesized composition containing phosphonoacetic acid demonstrates antiviral activity against herpesviruses and cytomegalovirus without cytotoxicity in cell cultures.
A manufacturable technology for the production of an antiviral composition containing phosphonoacetic acid, involing РН-alkylation of dimethyl phosphite with methyl chloroacetate under phase-transfer conditions and subsequent in situ hydrolysis of the intermediate product, was developed. The composition showed expressed antiviral effect against herpesviral infections caused by herpes simplex virus 1 and 2 and cytomegalovirus. The composition in the effective concentration range was found to exhibit no cytotoxic effect on VERO green monkey kidney and М-19 human diploid cell cultures. The resulting data suggest potential uses of the composition as an antiviral agent in practical medicine and as an antiviral additive to synthetic detergents for sanitation in health care and food production facilities.
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Lm et al. (2015) studied Herpesviral infections (HSV-1, HSV-2, cytomegalovirus). Composition containing phosphonoacetic acid was evaluated on Antiviral effect and cytotoxicity. A composition containing phosphonoacetic acid showed antiviral effects against herpes simplex virus 1 and 2 and cytomegalovirus without cytotoxic effects on VERO and M-19 cell cultures.
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