A proposal for a detailed geometrical pathway for the hydrolysis of substrates Y2PO−X and RCO−X, under the influence of zinc complexes or hydrolytic zinc enzymes, has been yielded by the combination of a kinetic study and a structure correlation analysis (see diagram). The essentials of this pathway are a four-center interaction between the Zn−OH and P−X or C−X units in the activation process and a Berry pseudorotation at zinc during the bond-breaking/bond-making process.
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Rombach et al. (1999) studied this question.