The Relation of Albumin to Precipitable Iodine of Serum 1

By correlation with clinical manifestations of thyroid disease, by comparison with basal metab- olism, and serum lipids, and by studies of the effects of removal of the thyroid and the adminis- tration of thyroid substance and thyroxine, it has been established that the precipitable iodine of the blood serum is, under usual circumstances, a most accurate measure of the activity of the thyroid gland (1 to 6).There is, indeed, reason to be- lieve that the precipitable iodine may be largely, if not chiefly, composed of thyroid hormone.Thy- roxine, added to normal serum, attaches itself